Так, в импортных источниках и ищем))
"Research evaluating the healing properties of GH/IGF-1 is in a more advanced stage. As shown in the previous paragraph, basic studies both in humans and animals have largely demonstrated the positive effects of GH/IGF-1 on tendons (increased tenocytes proliferation and collagen production, increased stem cells number and prevention of their death induced by anoxia). Moreover, studies have shown that this activity is mainly due to local production of IGF rather than to circulating levels of GH/IGF-1 complex. This finding is relevant because suggests the possibility of IGF-1 delivering in areas of tendon pathology, avoiding the side effects of a systemic administration.
These studies have prompted specific experiments to ascertain whether GH-IGF1 could be an useful tool for tendon healing. The results in animal models are promising. IGF-1 injection promotes tendon and ligament healing after collagenase-induced tissue atrophy or ligament disruption48. These findings are substantiated by a retrospective study performed in 40 cases of horse superficial digital flexor tendonitis. The intra-lesional administration of IGF-1 (25 or 50 μg every other day for 4 or 5 treatments) enhanced healing, as shown by the decrease of ultrasonographic lesions severity, although not to the point to return the horses to sport activities48.
Several human studies confirm animal experiments. Human tendon cells cultured in 3D with IGF-I supplementation showed an increased gene expression for collagen, tenomodulin and scleraxis49. Healthy humans, who receive either weeks of GH administration or acute injection of IGF-1, demonstrate increased expression and synthesis of collagen in muscle and tendon32. The local injections of recombinant IGF-1 into the patella tendon increased the collagen FSR and procollagen type I N-terminal propeptide (a marker for type I collagen synthesis) in the peritendinous fluid of healthy individuals50. Not only IGF-1 but also GH provides positive results. In a randomized study, two injections of GH in the patellar tendon of ageing subjects increased collagen synthesis rate 3–4 hours after the second injection, and showed a tendency to higher collagen FSR. Systemic IGF-1 remained unchanged, but interstitial IGF-I increased in GH treated tendons compared with saline treated tendons. This confirms that GH stimulatory effects on tendinous collagen synthesis involves local IGF-1 production50. Besides these observations, patients with Ehlers-Danlos syndrome (an inherited connective tissue disorder), treated with 1 mg of IGF-1 injected in the patellar tendon, showed an increase in the protein synthesis rate in comparison with the controlateral tendon used as control35.
On the other hand, exercise leads to activation of the systemic GH/IGF-1 axis39. Engineered ligaments treated with serum obtained from young healthy men after exercise resulted in more collagen and improved tensile strength in comparison to those treated with serum from resting men. In synthesis, results obtained in different experimental conditions lead to the concordant conclusion that GH/IGF-1 supplementation has positive effects which can favour tendon healing in humans.
Especially elderly people, characterized by an age-dependent decline in the GH/IGF-1 activity, may benefit from local GH-IGF-1 administration. It is well known that elderly individuals show lower content of structural proteins in tendons, reduced magnetic resonance imaging tendon signal intensities, and an increase in tendon cross-links due to advanced glycation end products deposition. The GH/IGF-1 axis seems to be important for the maintenance of the structural proteins within these tissues. To assess whether GH administration could hasten rehabilitation, aged individuals had one leg immobilized two weeks, followed by 6 weeks of retraining. Therefore, the legs immobilized and retrained were divided in two groups, the first receiving daily injections of recombinant GH, and the second saline solution as placebo. Several properties of the patellar tendon, including the cross sectional area, and biomechanical properties were measured, and the ratios type I/III and IGF-1 levels were evaluated in tendon biopsies. The group receiving GH injections showed an increase of patellar tendon cross sectional area and stiffness, associated to an increase of IGF-1. From these data it may be inferred that local GH administration may be useful to improve healing in patients during rehabilitation of tendon and ligament injuries and postsurgery51.
In conclusion, the relationships between hormones and tendons are complex and not fully understood. However, several experimental data suggest that some hormones (mainly GH/IGF-1) may offer significant advances in addition to present conservative treatments for human tendon diseases. A crucial point is to ascertain whether the local administration can be therapeutical, to avoid systemic interactions and undesirable effects. Because tendons injuries are frequent, often with long lasting sequels, this promising therapeutic approach deserves further clinical research."
GH = growth hormone
Написано много, теоретически должно действовать, но клинических исследований (нормальных) я пока не видел. Т.е. под микроскопом структура сухожилий улучшалась, но становится ли от этого лучше, неизвестно)). Это выдержка из обзора по гормональному лечению травм (
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310744/). Как видите, исследования проводятся, но в основном гистологические, эксперименты на мышах и т.п. Такого, чтоб кто-то взял и пролечил 100 человек с одной патологией гормоном роста, я не нашел пока. Видимо, есть какие-то этические причины))
Лично я считаю, что гормон роста может помочь при некоторых травмах. Но этот вопрос пока не исследован достаточно, чтоб что-то утверждать.
Имеются, например, и противоречивые данные исследований... (одно из них -
https://www.ncbi.nlm.nih.gov/pubmed/23636184)